Autoimmune Disease Biomarkers SLE, RA, Sjogren

Discover Biomarkers to Improve Disease Characterization, Patient Stratification and Response Prediction Using ImmunoINSIGHTS Autoantibody Profiling Platform

Autoimmune diseases are chronic, generally progressing diseases that are difficult to diagnose, resulting in late treatment. These diseases are well known for their heterogeneity which can cause similar clinical presentation, with different underlying pathology across multiple diseases. This causes challenges when recruiting patients to trials or designing research project cohorts, leading to sub-optimal performance of clinical studies

Case study: Ensuring enrolment of an appropriate SLE patient population: Patient clustering based on shared autoantibody reactivity.

Oncimmune performed an autoantibody profiling analysis of 69 patients recruited onto a clinical trial in Systemic lupus erythematosus (SLE). This demonstrated that SLE in fact consists of 5 sub-types of disease based on their autoantibody profiles. Patients with large number of autoantibodies were more likely to suffer from Lupus nephritis (Blue and red bars)






Source: Budde P. et al., Multiparametric detection of autoantibodies in systemic lupus erythematosus. Lupus. 2016 Jul;25(8):812-22.
doi: 10.1177/0961203316641770

, provides biomarker discovery for various applications:

• the understanding of autoimmune disease pathology
• early diagnosis and subgrouping of patients
• predicting response to therapy
• disease activity monitoring and prediction of flare-ups

ImmunoINSIGHTS™ is a comprehensive and powerful platform adding clinical significance for diagnosis and characterization of diseases for a wide range of autoimmune diseases :

• Chronic Inflammatory Demyelinating Polyneuropathy (CIPD)
• Colitis
• Hidradenitis Suppurativa (HS)
• Multiple Sclerosis (MS)
• Systemic Lupus Erythematosus (SLE) with & without nephritis:
• Sjörgen’s Syndrome
• Systemic Sclerosis (SSc)
• Rheumatoid Arthritis (RA)
• Rare Autoimmune Diseases

Autoantibodies are also applied in clinical research when assessing the autoimmune responses involved in a large number of diseases, including neonatal, neurological and infectious diseases.

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