Paradoxical sex-specific patterns of autoantibodies response to SARS-CoV-2 infection

16 August 2022

Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection

Yunxian Liu, Joseph E. Ebinger, Rowann Mostafa, Petra Budde, Jana Gajewski, Brian Walker, Sandy Joung, Min Wu, Manuel Bräutigam, Franziska Hesping, Elena Rupieper, Ann-Sophie Schubert, Hans-Dieter Zucht, Jonathan Braun, Gil Y. Melmed, Kimia Sobhani, Moshe Arditi, Jennifer E. Van Eyk, Susan Cheng & Justyna Fert-Bober

(extract from  J Transl Med, access full publication: Journal of Translational Medicine volume 19, Article number: 524 (2021)


Our results reveal that prior SARS-CoV-2 infection, even in the absence of severe clinical disease, can lead to a broad AAB response that exhibits sex-specific patterns of prevalence and antigen selectivity. Further understanding of the nature of triggered AAB activation among men and women exposed to SARS-CoV-2 will be essential for developing effective interventions against immune-mediated sequelae of COVID-19.